USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: P07737 USC-OGP 2-DE database:  P07737 P07737 General information about the entry View entry in simple text format Entry name PROF1_HUMAN Primary accession number P07737 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Profilin-1; AltName: Full=Epididymis tissue protein Li 184a; AltName: Full=Profilin I;. Gene name Name=PFN1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-1087: pI=8.11; Mw=15743 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1349: pI=4.76; Mw=13831 SPOT OGP-1350: pI=8.13; Mw=13768 SPOT OGP-1352: pI=8.49; Mw=13705 Cross-references UniProtKB/Swiss-Prot P07737; PROF1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PROF1_HUMAN Primary accession number P07737 Secondary accession number(s) Q53Y44 Sequence was last modified on  January 23, 2007 (version 2) Annotations were last modified on  March 15, 2017 (version 191) Name and origin of the protein Description RecName: Full=Profilin-1; AltName: Full=Epididymis tissue protein Li 184a; AltName: Full=Profilin I; Gene name Name=PFN1 Encoded on Name=PFN1 Keywords 3D-structure; Acetylation; Actin-binding; Amyotrophic lateral sclerosis; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Isopeptide bond; Neurodegeneration; Phosphoprotein; Reference proteome; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL J03191; AAA36486.1; -; mRNA EMBL GU727630; ADU87632.1; -; mRNA EMBL BT007001; AAP35647.1; -; mRNA EMBL AK312168; BAG35102.1; -; mRNA EMBL CR407670; CAG28598.1; -; mRNA EMBL CH471108; EAW90381.1; -; Genomic_DNA EMBL CH471108; EAW90383.1; -; Genomic_DNA EMBL CH471108; EAW90384.1; -; Genomic_DNA EMBL BC002475; AAH02475.1; -; mRNA EMBL BC006768; AAH06768.1; -; mRNA EMBL BC013439; AAH13439.1; -; mRNA EMBL BC015164; AAH15164.1; -; mRNA EMBL BC057828; AAH57828.1; -; mRNA CCDS CCDS11061.1; -; . PIR A28622; A28622; . RefSeq NP_005013.1; NM_005022.3; . UniGene Hs.494691; -; . PDB 1AWI; X-ray; 2.20 A; A/B=3-140 PDB 1CF0; X-ray; 2.20 A; A/B=3-140 PDB 1CJF; X-ray; 2.30 A; A/B=2-140 PDB 1FIK; X-ray; 2.30 A; A=2-140 PDB 1FIL; X-ray; 2.00 A; A=2-140 PDB 1PFL; NMR; -; A=2-140 PDB 2PAV; X-ray; 1.80 A; P=2-140 PDB 2PBD; X-ray; 1.50 A; P=2-140 PDB 3CHW; X-ray; 2.30 A; P=2-140 PDB 4X1L; X-ray; 2.16 A; A=1-140 PDB 4X1M; X-ray; 2.17 A; A=1-140 PDB 4X25; X-ray; 2.23 A; A/B=1-140 PDBsum 1AWI; -; . PDBsum 1CF0; -; . PDBsum 1CJF; -; . PDBsum 1FIK; -; . PDBsum 1FIL; -; . PDBsum 1PFL; -; . PDBsum 2PAV; -; . PDBsum 2PBD; -; . PDBsum 3CHW; -; . PDBsum 4X1L; -; . PDBsum 4X1M; -; . PDBsum 4X25; -; . ProteinModelPortal P07737; -; . SMR P07737; -; . BioGrid 111237; 63; . DIP DIP-30N; -; . IntAct P07737; 44; . MINT MINT-1372667; -; . STRING 9606.ENSP00000225655; -; . DrugBank DB07908; 7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARIN; . Allergome 907; Hom s Profilin; . iPTMnet P07737; -; . PhosphoSitePlus P07737; -; . SwissPalm P07737; -; . BioMuta PFN1; -; . DMDM 130979; -; . DOSAC-COBS-2DPAGE P07737; -; . OGP P07737; -; . REPRODUCTION-2DPAGE IPI00216691; -; . UCD-2DPAGE P07737; -; . EPD P07737; -; . PaxDb P07737; -; . PeptideAtlas P07737; -; . PRIDE P07737; -; . TopDownProteomics P07737; -; . DNASU 5216; -; . Ensembl ENST00000225655; ENSP00000225655; ENSG00000108518; . GeneID 5216; -; . KEGG hsa:5216; -; . UCSC uc002gaa.5; human; . CTD 5216; -; . DisGeNET 5216; -; . GeneCards PFN1; -; . GeneReviews PFN1; -; . HGNC HGNC:8881; PFN1; . HPA CAB037134; -; . HPA CAB037140; -; . MalaCards PFN1; -; . MIM 176610; gene; . MIM 614808; phenotype; . neXtProt NX_P07737; -; . OpenTargets ENSG00000108518; -; . Orphanet 803; Amyotrophic lateral sclerosis; . PharmGKB PA33219; -; . eggNOG KOG1755; Eukaryota; . eggNOG ENOG41126PD; LUCA; . GeneTree ENSGT00390000010143; -; . HOGENOM HOG000171592; -; . HOVERGEN HBG053683; -; . InParanoid P07737; -; . KO K05759; -; . OMA HLRRAQY; -; . PhylomeDB P07737; -; . TreeFam TF331744; -; . Reactome R-HSA-114608; Platelet degranulation; . Reactome R-HSA-376176; Signaling by Robo receptor; . Reactome R-HSA-4086400; PCP/CE pathway; . Reactome R-HSA-5663220; RHO GTPases Activate Formins; . SIGNOR P07737; -; . ChiTaRS PFN1; human; . EvolutionaryTrace P07737; -; . GeneWiki Profilin_1; -; . GenomeRNAi 5216; -; . PMAP-CutDB P07737; -; . PRO PR:P07737; -; . Proteomes UP000005640; Chromosome 17; . Bgee ENSG00000108518; -; . CleanEx HS_PFN1; -; . ExpressionAtlas P07737; baseline and differential; . Genevisible P07737; HS; . GO GO:0072562; C:blood microparticle; IDA:UniProtKB; . GO GO:0005938; C:cell cortex; IDA:UniProtKB; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0043005; C:neuron projection; IEA:Ensembl; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0045202; C:synapse; IEA:Ensembl; . GO GO:0003779; F:actin binding; IPI:UniProtKB; . GO GO:0003785; F:actin monomer binding; IDA:UniProtKB; . GO GO:0000774; F:adenyl-nucleotide exchange factor activity; IDA:UniProtKB; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0005546; F:phosphatidylinositol-4; 5-bisphosphate binding; IDA:UniProtKB GO GO:0070064; F:proline-rich region binding; IPI:UniProtKB; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0030036; P:actin cytoskeleton organization; IEA:InterPro; . GO GO:0071363; P:cellular response to growth factor stimulus; IEA:Ensembl; . GO GO:0032232; P:negative regulation of actin filament bundle assembly; IMP:UniProtKB; . GO GO:0030837; P:negative regulation of actin filament polymerization; IDA:UniProtKB; . GO GO:0051497; P:negative regulation of stress fiber assembly; IMP:UniProtKB; . GO GO:0001843; P:neural tube closure; IEA:Ensembl; . GO GO:0032233; P:positive regulation of actin filament bundle assembly; IBA:GO_Central; . GO GO:0030838; P:positive regulation of actin filament polymerization; IGI:UniProtKB; . GO GO:0032781; P:positive regulation of ATPase activity; IDA:UniProtKB; . GO GO:0051054; P:positive regulation of DNA metabolic process; IEA:Ensembl; . GO GO:0010634; P:positive regulation of epithelial cell migration; IMP:UniProtKB; . GO GO:1900029; P:positive regulation of ruffle assembly; IMP:UniProtKB; . GO GO:0051496; P:positive regulation of stress fiber assembly; IEA:Ensembl; . GO GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl; . GO GO:0050434; P:positive regulation of viral transcription; IEA:Ensembl; . GO GO:0050821; P:protein stabilization; IDA:UniProtKB; . GO GO:0060071; P:Wnt signaling pathway; planar cell polarity pathway; TAS:Reactome CDD cd00148; PROF; 1; . InterPro IPR005455; PFN; . InterPro IPR005454; Profilin1/2/3_vertebrate; . InterPro IPR027310; Profilin_CS; . Pfam PF00235; Profilin; 1; . PRINTS PR01639; PROFILINMAML; . SMART SM00392; PROF; 1; . SUPFAM SSF55770; SSF55770; 1; . PROSITE PS00414; PROFILIN; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

[Home]